Azo dyestuffs and process for the manufacture thereof



Patented Aug. 8, 1939 UNITED sTArss na al? QFFIfiE AZO DYES'EUFFS AND PROCESS FOR THE MANUFACTURE THERE-(BF Beunies, Etablissernents Kuhlrnan, Paris,

France, a corporation of France Ne Drawing.

3 Claims.

This invention relates to new azo-dyestufis and processes for the manufacture thereof.

It is known that Z-nitrobenzene-Iii-disulphonic acid is obtained not directly by sulphona- 6 tion but by heating 1-chloro-Z-nitrobenzene-isulphonic acid with sodium sulphite in an aqueous medium.

In the same way up to the present it has not been possible to carry out industrially the preparation of the disulphochloride of this acid; the action of chlorsulphonic acid or phosphorus pentachloride has produced in fact l-chloro-2- nitrobenzene4-sulphochloride.

The production of derivatives of Z-nitro-benbene-l,4-disu1phonic acid is, therefore, only possible by indirect methods.

In particular for the preparation of products of the type:

up to the present one of the following methods has been used:

However, these two processes only permit of Application .i'uly 22, 1938, Seriai In France September 4, 1937 producing one particular class of derivatives of Z-nitrobenzcne-IA-disulphonic acid, those derived from sulphones nitrated in the 2-position. Now, if the sulphonamides of the general formula:

R1 SOT-N These disulphides when subjected to the action of chlorine in an 85-90% acetic acid medium. give the sulphochlorides of the formula:

S OzCl These sulphochlorides can be condensed with ammonia or primary or secondary amines in such a manner as to obtain the products of the formula:

SOz-N in which R3 and R4 have the same significance as R1 and R2, which products, by reduction, give under particularly interesting conditions of yield and purity the amines lhe present invention concerns the production of new azo-dyestuffs by diazotization of the amines of the above general formula and coupling of the azo-derivatives thus obtained with the customary coupling components. According to the coupling components selected it is possible to obtain dyestuffs utilisable for the most varied purposes.

With the naphthol-sulphonic, naphthylaminesulphonic and amino-naphthol-sulphonic acids, amino-11apl1thol-sulphonic acids substituted on the nitrogen and aryl-pyrazolone sulphonic acids there are obtained for example dyestuils for W001. With coupling components of substantive character such as the arylides of the orthohydroXy-carboxylic acids and of the acyl-acetic acids it is possible to obtain in substance or on the fibre insoluble dyestuffs of good fastness properties. The preparation of such dyestuffs on the fibre can be carried out by one of the customary methods with or without the intermediate production of diazo-amino-derivatives, nitrosamines, Schifi bases, diazo-sulphonates and so on. The same dyestuffs, prepared in sub stance, can be utilised for the coloration of varnishes, lacquers, latex, paper, plastic materials, artificial silks in the mass, rubber and so on.

The following examples illustrate the invention without limiting the same thereto:

Example 1 700 grams of 1-chloro-2-nitro-4-diethylsulphonamidobenzene are dissolved at -75 C. in 1800 ccs. of ethyl alcohol. There is caused to how in with brisk stirring in order to avoid separation into two layers, a hot solution prepared from 315 grams of NazSQHzO, 43 grams of sulphur and 1000 cos. of alcohol. It may be necessary to cool in the course of the introduction. The disulphide precipitates abundantly. The whole is allowed to cool with stirring and then the crystals are filtered and are washed with alcohol and then with Water.

Weight after drying grams 650 Melting point C 198 Yield percent After recrystallisation from glacial acetic acid, the 4,4-(diethylsulphonarnido) -2,2'-dinitro-1,l'- diphenyl-disulphide is produced in the form of large greenish yellow prisms.

Melting point 190 C.

650 grams of the above disulphide are pasted in 2500 ccs. of glacial acetic acid and 300 ccs. of water. A current of chlorine is caused to pass through first rapidly and then more slowly while energetically stirring the mass, the temperature being prevented from exceeding 35 C. At the end of some hours the disulphide has entered completely into solution. Chlorine is continuously passed until a test portion, poured in ice,

melts at 98-100 C. This results at the end of about 10 hours. The whole is poured on ice and the crystals filtered and washed with cold water.

Dry weight "grams" 740 Melting point 0.. 98-100 Weight in paste gran1s 1100 After recrystallisation from acetic acid the 1- diethylsulphonamido-3-nitrobenzene 4 sulphochloride is formed in very large slightly greenish yellow prisms. Melting point 102 C.

200 grams of the paste of sulphochloride are brought into suspension in 300 ccs. of water. There are added with stirring 400 ccs. of. 30% diethylamine solution and the whole is heated for one hour to boiling with good agitation. The crude product after filtration is recrystallised from alcohol. It is produced in the form of fine yellowish crystals melting at 118 C. Dry Weight grs.

After reduction in dilute acetic acid of 60% strength with zinc dust there are isolated with a yield of 85% magnificent crystals which are perfectly colourless and the melting point of which is 172 C.

This new base has for its formula:

Calculated Found Analysis cacaoom CA7 00m Hum-i bJ LHODN In the same manner it is possible to prepare for example by replacing the diethylamine by dimethylamine the 1-diethylsulphonamido-3- nitro-4-dimethylsulphonamido-benzene the melting point of which after crystallisation from alcohol is C. This body is produced in the form of fine yellowish crystals which on reduction give the 1-diethylsulphonamido-3-arnino-4- dimethylsulphonamido-benzene, colourless crystals the melting point of which is 184 C.

S OeN iii) colourless prisms". Melting point 133 C. after crystallisation from alcohol.

CgHr,

I /C2H5 S OgN By replacing the ethylaniline by methylaniline there is obtained the l-diethylsulphonamido-IS- nitro-4-methyl-phenyl-sulphonainido benezene, melting point after crystallisation from acetic acid (3., which is produced in the form of fine needles agglomerated in slightly greenish tufts which by reduction give large colourless prisms of 1-diethyl-sulphonamido-3amino-4- methylphenyl-sulphonainidc-benzene. Melting point 137 C.

CzHs

SOBN SOzN Example 2 (a) 800 grams of 1-chlo-ro-2-nitro-e-dimethylsulphonamido-benzene are dissolved at 75 C. in 2500 cos. of ethyl alcohol. A boiling emulsion is made with 380 grams of Na2S,9I-I2O, 51 grams of sulphur and 800 cos. of alcohol which is prevented from separating into two layers before pouring gradually with energetic stirring into the alcoholic solution of the sulphonarnide. The disulphide precipitates as a voluminous mass which is difficult to stir. The whole is heated for one hour longer at Vii-30 C. and after cooling the product is washed first with alcohol and then with much water.

Dry weight 780 grs.

Melting point 275-280 C. with decomposition or more exactly 280 C. with decomposition, after recrystallisation from acetic acid, which solvent dissolves it fairly difficultly even on boiling.

The dilute alcoholic solution, after decolorisation with carboraffin, deposits, after acidification with acetic acid, a small quantity, 50 grs. after drying, of 1-dimethyl-sulphonamido-S-nitro-Q- thiophenol wl'L'ch melts at 162-165 C. with oxidation on the mercury bath with i e-formation of the disulphide which is produced in. the form of large yellowish prisms after recrystallisation from acetic acid.

(b) 500 grs. of 4, 4-di-(dimethylsulphonamido) -2, 2-dinitro-1, 1'-dipenhyl-disulphide are brought into suspension in 2500 cos. of glacial acetic acid and 300 cos. of water. A rapid cur rent of chlorine is passed through until the temperature rises to Bil-55 C. This temperature is maintained by regulating the delivery of chlorine. The disulphide gradually passes into solution. The passage of chlorine is continued until a. test portion diluted and filtered gives a product which melts at 147-148" C. and is entirely soluble in dilute sodium carbonate. The whole is left over night while allowing to cool, then poured on ice, filtered and washed.

Dry weight 545 grs., melting point 149-150 0.

Yield about 87%.

After recrystallisation from acetic acid the 1- dimethyl-sulphonamido-3-nitrobenzen;e 4 sulphochloride is produced in the form of colourless needles. Melting point 151 C.

(c) grs. of crude l-dimethylsulphonamido- 3-nitrobenzene-4-sulphochloride, melting point 149-150 C., are dissolved in 500 cos. of chlorobenzene. There are introduced with stirring 70 grs. of 95% diethylamine. The temperature rises to 65 C. After 10 minutes stirring the whole is cooled and distilled in steam in the presence of 100 cos. of concentrated HCl. The crystals are filtered and dried; dry weight grs. melting point 128-132 C.

After recrystallisation from acetic acid the compound gives fine slightly yellowish plates. Melting point 134 C.

By reduction with 50% acetic acid and zinc there is obtained 1-dimethylsulphonamido-3- amine-4diethyl-sulphonamido benzene which after crystallisation from alcohol is produced in Melting point 174 C.

CH3 s Or-N fine colourless needles.

CH5 S OQN NHz With methylaniline and the same sulphochloride there is produced the l-dimethylsulphonamido 3 nitro 4 -methylphenyl-su1phonamido benzene in slightly yellowish crystals melting at C. after crystallisation from acetic acid and which by reduction gives l-dimethylsulphonami- Clo-3-amino-4-methyl-phenyl-sulphonamido-benzene which is produced in the form of colourless needles melting at 144 C.

OzN

Example 3 300 grs. of 1-chloro-2-nitro-4-methylphenyl sulphonamido-benzene are dissolved at 70 C. in 2000 cos. of ethyl alcohol. There is prepared as indicated above a solution of 127 grs. of

and 18 grs. of sulphur in 500 cos. of ethyl alcohol. The solution of disulphide (which on standing separates into two layers) is caused to flow gradually into the solution of sulphonamido. The reaction is fairly violent. After complete introduction the whole is heated again for one hour to 75 C. The whole is allowed to cool with stirring and the crystals are filtered and washed, first with alcohol then with water.

Weight after drying 250 grs.

Melting point 206-207" C.

After recrystallisation from acetic acid there are obtained voluminous yellowish crystals. Melting point 208 C.

r NOz NO2\ crystallisation from acetic acid gives fine slightly yellowish needles. Melting point 150 C.

By reduction in the customary manner there are isolated large colourless prisms. Melting point after crystallisation from alcohol 157 C. The alcoholic solution exhibits a magnificent blue fluorescence.

Example 4 The majority of these bases give very dissociated hydrochlorides which accordingly are difficultly diazotised. It may be necessary to carry out the diazotisation in a solvent medium, for example acetic acid.

30 grams of 1,4-di-(diethylsulphonamido)-3- amino-benzene are pasted with 100 cos. of glacial acetic acid and cos. of concentrated HCl. After external cooling the whole is diazotised with 15 cos. of 50% sodium nitrite solution then 20 grs. of zinc chloride are added dissolved in 50 cos. of Water and 15 cos. of HCl.

The diazo compound is then precipitated with 500 cos of salt water of 24 Be. There are obtained brilliant slightly yellowish plates which are filtered and washed with salt water.

Dry weight 50 grs. which are mixed intimately with 90 grs. of anhydrous aluminium sulphate.

The slightly yellowish powder obtained is easily soluble in water and the diazo solution obtained gives on skeins of cotton, impregnated with for example arylide of fi-hydroxy-naphthoic acid, a whole range of yellowish orange shades of good fastness properties.

It is likewise possible in many cases to isolate the diazoniuin chloride without stabilising.

20 grs. of l-diethyl-sulphonamido-Ii-aminolmethyl-phenyl-sulphonamido-benzene are pasted inl50 cos. of glacial acetic acid and 100 cos. of concentrated HCl. After external cooling the whole is diazotised with 15 cos. of 50% sodium nitrite diluted with its own volume of water. After 10 minutes stirring the whole is diluted with 600 cos. of salt water of 24 B. The yellow needles of the diazonium chloride are filtered, washed with salt Water and dried at a low temperature.

Dry weight 35 grs. The product is mixed with 75 grs. of anhydrous aluminium sulphate whereby a yellow powder is obtained fairly easily soluble in water.

There can be used as coupling components the arylides of fl-hydroxy-naphthoic acid, of hydroxycarbazole carboxylic acids, hydroxyanthracene carboxylic acids and so on, the acyl acetyl derivatives, the pyrazolones and so on. The dyestuffs can be produced on the fibre or in substance.

The following table indicates the shades obtained by coupling on the fibre the diazo derivatives of different amines according to the invention with different coupling components:

Di azo-component Coupling component Shade on cotton z-diethylsulphonamido-5-mcthylphenylsulphonamidoamino benzene Diacetoacetyl-o-tolidinc 2.3-hydroxy naphthoic ac d Anil1 de.

Yellow.

Orange. Reddisli orange.

Orange D0.

Dp. Rcddish orange.

a-Naplitliylarnide Orange.

o-Anisididc p-Ch 1oro-0'anisidide Do.

2.LdlmOthOXy-5-0h10r0811i1id6. Brownish orange.

Diacetoacetyl-o-tolidinc Yellow.

2.3-hydroxy ncphthoic acid An1l1 le Golden orange. m-N1tran1l1dc Orange. fi-Naphthylamid Do. 5-chloro-o-t0luidid Do. p-Anisididc D0. o-Toluidide D0. a-Naplit hylamide Brownislired. o-Anis1d1de Orange red. p-Chloro-o'onisididc... Orange. .4-dimethoxy-fichlmoanilidc. Ycllowish brown.

Diazo-component Coupling component Shade on cotton 2-dimetnylsulphonamide-5-methylphenylsulphonamide-amino benzene Diacetoacetyl-o-tolidine Yellow.

2.3-l1ydroxy naphthoic acid Anilide Orange. m-Nitranilide Do. fl-Naphthylamide. Reddish orange. fi-chloro-o-toluidide Orange. p-Anisidide Do. o-Toluidide Do. a-Naphthylamide Reddish orange. o-Anisidide Orange. p-Chloro-o-anisidide Do. 2.4-dimethoxy-S-chloroanilide. Brownish orange.

Diacetoacetyl-o-tolidine Yellow.

2.3-hydroxy naphthoic acid Anilide Golden orange. rn-Nitranilide. Orange. B-Naphthylarnide Reddish orange. 5-ch1oro-o-toluidide.. Orange.

. Reddish orange. Orange.

A Orange red. p-Ohloro'o-anisldide Orange scarlet. 2. i-dimethoxy-Ev-chloro-amlide Orange brown.

Diacetoacetyl-o-tolidine Yellow.

2.3-hydroxy naphthoic aeid Anilide Orange. m-Nitranilide Do. fl-Naphthylamrde. Do. 5-cl1loro-otoluidide Do. p-Anisidide. Do. -Ioluidide D0. a-Naphthylamida Brownish orange. o-Anisidide Brownish orange.

Orange.

o. Brownish orange.

Diacetoacetyl-o-tolidine Yellow. 2.3-hydroxy naphthoic acid- Anilide Orange.

Red.

. Orange.

p-Chloro-o-anisidide... 0.

2.4-dimethoxy--chl0r0-anilide Brown.

What I claim is: 1. The azo-dyestufis of the following probable general formula:

50 in which R1, R2, R3, R4 are members of the group consisting in the hydrogen atom, alkyl, aralkyl, aryl and cycloalkyl groups and A is the residue of a coupling component of the group consisting of the arylides of ortho-hydroxy-car- 55 boxylic acids and of acyl acetic acids.

2. Process for the manufacture of azo-dyestuffs which consists in coupling in substance a diazo derivative of an amine having following general formula: 60 /R1 SO2N Rs SOPN wherein R1, R2, R3, R4 stand for members of the group consisting of hydrogen, alkyl, aralkyl, aryl and cycloalkyl groups, with a member of the group consisting of the arylides of orthohydroxy carboxylic acids and acylacetic acids.

3. Process for the manufacture of azo-dyestuffs which consists in coupling on the fiber a diazo derivative of an amine having following general formula:

PIERRE PETITCOLAS. 

